Journal of the American College of Radiology
Volume 6, Issue 11 , Pages 800-803 , November 2009

Treatment Delays Using an Automated Afterloading Low-Dose-Rate Brachytherapy System

  • Colleen M. DesRosiers, PhD

      Affiliations

    • Department of Radiation Oncology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • Department of Obstetrics and Gynecology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • Corresponding Author InformationCorresponding author and reprints: Colleen DesRosiers, PhD, Melvin and Bren Simon Cancer Center, Department of Radiation Oncology, 535 Barnhill Drive, RT041, Indianapolis, IN 46202
    • ,
  • Eric Slessinger, MS

      Affiliations

    • Department of Radiation Oncology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • Department of Obstetrics and Gynecology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • ,
  • Jeanne Schilder, MD

      Affiliations

    • Department of Radiation Oncology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • Department of Obstetrics and Gynecology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • ,
  • Frederick Stehman, MD

      Affiliations

    • Department of Radiation Oncology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • Department of Obstetrics and Gynecology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • ,
  • Indra J. Das, PhD

      Affiliations

    • Department of Radiation Oncology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • Department of Obstetrics and Gynecology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • ,
  • Paul DesRosiers, MD

      Affiliations

    • US Oncology, Indianapolis, Indiana
    • ,
  • Higinia Cardenes, MD, PhD

      Affiliations

    • Department of Radiation Oncology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • Department of Obstetrics and Gynecology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • ,
  • Peter A.S. Johnstone, MD

      Affiliations

    • Department of Radiation Oncology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
    • Department of Obstetrics and Gynecology, Indiana University School of Medicine/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

References 

  1. Nag S, Chao C, Erickson B, et al. American Brachytherapy Society The American Brachytherapy Society recommendations for low-dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 2002;52:33–48
  2. Wolfson AH. Conventional radiation therapy of cervical cancer. Semin Surg Oncol. 1999;16:242–246
  3. Wang JZ, Li XA, D'Souza WD, et al. Impact of prolonged fraction delivery times on tumor control: a note of caution for intensity-modulated radiation therapy (IMRT). Int J Radiat Oncol Biol Phys. 2003;57:543–552
  4. Lin PS, Wu A. Not all 2 gray radiation prescriptions are equivalent: cytotoxic effect depends on delivery sequences of partial fractionated doses. Int J Radiat Oncol Biol Phys. 2005;63:536–544
  5. Spanos WJ, Pajak TJ, Emami B, et al. Radiation palliation of cervical cancer. J Natl Cancer Inst Monogr. 1996;21:127–130
  6. Johnstone PAS, Wassermann EM, O'Connell PG, et al. Lumbosacral plexopathy secondary to hyperfractionated radiation therapy: a case presentation and literature review. Radiat Oncol Invest. 1993;1:126–130
  7. Fyles A, Keane TJ, Barton M, et al. The effect of treatment duration in the local control of cervix cancer. Radiother Oncol. 1992;25:273–279
  8. Girinsky T, Rey A, Roche B, et al. Overall treatment time in advanced cervical carcinomas: a critical parameter in treatment outcome. Int J Radiat Oncol Biol Phys. 1993;27:1051–1056
  9. Hoffstetter S, Marchal C, Peiffert D, et al. Treatment duration as a prognostic factor for local control and survival in epidermoid carcinomas of the tonsillar region treated by combined external beam irradiation and brachytherapy. Radiother Oncol. 1997;45:141–148
  10. Haie-Meder C, Kramar A, Lambin P, et al. Analysis of complications in a prospective randomized trial comparing two brachytherapy low dose rates in cervical carcinoma. Int J Radiat Oncol Biol Phys. 1994;29:953–960
  11. Newman G. Increased morbidity following the introduction of remote afterloading, with increased dose rate, for cancer of the cervix. Radiother Oncol. 1996;39:97–103
  12. Rodrigus P, De Winter K, Venselaar JL, et al. Evaluation of late morbidity in patients with carcinoma of the uterine cervix following a dose rate change. Radiother Oncol. 1997;42:137–141
  13. Polo A. Pulsed dose rate brachytherapy. Clin Translat Oncol. 2008;10:324–333
  14. Harms W, Weber KJ, Ehemann V, et al. Differential effects of CLDR and PDR brachytherapy on cell cycle progression in a syngeneic rat prostate tumour model. Int J Radiat Oncol Biol Phys. 2006;82:191–196
  15. Bachtiary B, Dewitt A, Pintilie M, et al. Comparison of late toxicity between continuous low dose rate and pulsed dose rate brachytherapy in cervical cancer patients. Int J Radiat Oncol Biol Phys. 2005;63:1077–1082
  16. Pomp J, Woudstra EC, Kampinga HH. Pulsed dose rate and low dose rate brachytherapy: comparison of sparing effects in cells of a radiosensitive and a radioresistent cell line. Radiat Res. 1999;151:449–453

PII: S1546-1440(09)00363-9

doi: 10.1016/j.jacr.2009.07.013

Journal of the American College of Radiology
Volume 6, Issue 11 , Pages 800-803 , November 2009

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