Journal of the American College of Radiology
Volume 5, Issue 1 , Pages 36-39, January 2008

Circulating Fibrocytes: Cellular Basis for NSF

  • Richard Bucala, MD, PhD

      Affiliations

    • Corresponding Author InformationCorresponding author and reprints: Richard Bucala, MD, PhD, Yale University School of Medicine, Department of Internal Medicine, 300 Cedar Street, Room S525 TAC, New Haven, CT 06520-8031

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.

Since the discovery of the circulating fibrocyte as a collagen-producing cell of the peripheral blood, the physiologic and pathologic role of this unique cell population has grown steadily. The present review summarizes the known biology of fibrocytes and discusses evidence for their role in the pathogenesis of nephrogenic systemic fibrosis. Possible mechanisms by which gadolinium may influence the activation or trafficking properties of fibrocytes leading to tissue fibrosis are discussed.

Key Words: Nephrogenic systemic fibrosis, nephrogenic fibrosing dermopathy, MRI contrast, circulating fibrocytes, pathogenesis

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PII: S1546-1440(07)00451-6

doi:10.1016/j.jacr.2007.08.016

Journal of the American College of Radiology
Volume 5, Issue 1 , Pages 36-39, January 2008

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